The Top Nonfiction Accounts of Epidemics and Pandemics

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A masterpiece of science reporting that tracks the animal origins of emerging human diseases.

The emergence of strange new diseases is a frightening problem that seems to be getting worse. In this age of speedy travel, it threatens a worldwide pandemic. We hear news reports of Ebola, SARS, AIDS, and something called Hendra killing horses and people in Australia―but those reports miss the big truth that such phenomena are part of a single pattern. The bugs that transmit these diseases share one thing: they originate in wild animals and pass to humans by a process called spillover. David Quammen tracks this subject around the world. He recounts adventures in the field―netting bats in China, trapping monkeys in Bangladesh, stalking gorillas in the Congo―with the world’s leading disease scientists. In Spillover Quammen takes the reader along on this astonishing quest to learn how, where from, and why these diseases emerge, and he asks the terrifying question: What might the next big one be?

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It’s the summer of 1854, and London is just emerging as one of the first modern cities in the world. But lacking the infrastructure-garbage removal, clean water, sewers-necessary to support its rapidly expanding population, the city has become the perfect breeding ground for a terrifying disease no one knows how to cure. As the cholera outbreak takes hold, a physician and a local curate are spurred to action-and ultimately solve the most pressing medical riddle of their time.

In a triumph of multidisciplinary thinking, Johnson illuminates the intertwined histories of the spread of disease, the rise of cities, and the nature of scientific inquiry, offering both a riveting history and a powerful explanation of how it has shaped the world we live in.

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A highly infectious, deadly virus from the central African rain forest suddenly appears in the suburbs of Washington, D.C. There is no cure. In a few days 90 percent of its victims are dead. A secret military SWAT team of soldiers and scientists is mobilized to stop the outbreak of this exotic “hot” virus. The Hot Zone tells this dramatic story, giving a hair-raising account of the appearance of rare and lethal viruses and their “crashes” into the human race. Shocking, frightening, and impossible to ignore, The Hot Zone proves that truth really is scarier than fiction.

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After decades spent assuming that the conquest of infectious disease was imminent, people on all continents now find themselves besieged by AIDS, drug-resistant tuberculosis, cholera that defies chlorine water treatment, and exotic viruses that can kill in a matter of hours.

Relying on extensive interviews with leading experts in virology, molecular biology, disease ecology, and medicine, as well as field research in sub-Saharan Africa, Western Europe, Central America, and the United States, Laurie Garrett’s The Coming Plague takes readers from the savannas of eastern Bolivia to the rain forests of the northern Democratic Republic of the Congo on a harrowing, fifty year journey through the history of our battles with microbes. This book is a work of investigative reportage like no other and a wake-up call to a world that has become complacent in the face of infectious disease—one that offers a sobering and prescient warning about the dangers of ignoring the coming plague.

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Veteran journalist Gina Kolata’s Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It presents a fascinating look at the true story of the world’s deadliest disease.

In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out.

Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for The New York Times, unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.

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The Great Plague is one of the most compelling events in human history—even more so now, when the notion of plague has never loomed larger as a contemporary public concern.

The plague that devastated Asia and Europe in the 14th century has been of never-ending interest to both scholarly and general readers. Many books on the plague rely on statistics to tell the story: how many people died; how farm output and trade declined. But statistics can’t convey what it was like to sit in Siena or Avignon and hear that a thousand people a day are dying two towns away. Or to have to chose between your own life and your duty to a mortally ill child or spouse. Or to live in a society where the bonds of blood and sentiment and law have lost all meaning, where anyone can murder or rape or plunder anyone else without fear of consequence.

In The Great Mortality, author John Kelly lends an air of immediacy and intimacy to his telling of the journey of the plague as it traveled from the steppes of Russia, across Europe, and into England, killing 75 million people—one third of the known population—before it vanished.

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Over the course of history, yellow fever has paralyzed governments, halted commerce, quarantined cities, moved the U.S. capital, and altered the outcome of wars. During a single summer in Memphis alone, it cost more lives than the Chicago fire, the San Francisco earthquake, and the Johnstown flood combined.

In 1900, the U.S. sent three doctors to Cuba to discover how yellow fever was spread. There, they launched one of history’s most controversial human studies. Compelling and terrifying, The American Plague depicts the story of yellow fever and its reign in this country—and in Africa, where even today it strikes thousands every year. With “arresting tales of heroism,” (Publishers Weekly) it is a story as much about the nature of human beings as it is about the nature of disease.

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Upon its original publication, Plagues and Peoples was an immediate critical and popular success, offering a radically new interpretation of world history as seen through the extraordinary impact–political, demographic, ecological, and psychological–of disease on cultures. From the conquest of Mexico by smallpox as much as by the Spanish, to the bubonic plague in China, to the typhoid epidemic in Europe, the history of disease is the history of humankind. With the identification of AIDS in the early 1980s, another chapter has been added to this chronicle of events, which William McNeill explores in his new introduction to this updated editon.

Thought-provoking, well-researched, and compulsively readable, Plagues and Peoples is that rare book that is as fascinating as it is scholarly, as intriguing as it is enlightening. “A brilliantly conceptualized and challenging achievement” (Kirkus Reviews), it is essential reading, offering a new perspective on human history.

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A witty, irreverent tour of history’s worst plagues—from the Antonine Plague, to leprosy, to polio—and a celebration of the heroes who fought them

In 1518, in a small town in Alsace, Frau Troffea began dancing and didn’t stop. She danced until she was carried away six days later, and soon thirty-four more villagers joined her. Then more. In a month more than 400 people had been stricken by the mysterious dancing plague. In late-seventeenth-century England an eccentric gentleman founded the No Nose Club in his gracious townhome—a social club for those who had lost their noses, and other body parts, to the plague of syphilis for which there was then no cure. And in turn-of-the-century New York, an Irish cook caused two lethal outbreaks of typhoid fever, a case that transformed her into the notorious Typhoid Mary.

Throughout time, humans have been terrified and fascinated by the diseases history and circumstance have dropped on them. Some of their responses to those outbreaks are almost too strange to believe in hindsight. Get Well Soon delivers the gruesome, morbid details of some of the worst plagues we’ve suffered as a species, as well as stories of the heroic figures who selflessly fought to ease the suffering of their fellow man. With her signature mix of in-depth research and storytelling, and not a little dark humor, Jennifer Wright explores history’s most gripping and deadly outbreaks, and ultimately looks at the surprising ways they’ve shaped history and humanity for almost as long as anyone can remember.

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Over the past fifty years, more than three hundred infectious diseases have either emerged or reemerged, appearing in places where they’ve never before been seen. Years before the sudden arrival of COVID-19, ninety percent of epidemiologists predicted that one of them would cause a deadly pandemic sometime in the next two generations. It might be Ebola, avian flu, a drug-resistant superbug, or something completely new, like the novel virus the world is confronting today. While it was impossible to predict the emergence of SARS-CoV-2—and it remains impossible to predict which pathogen will cause the next global outbreak—by unraveling the stories of pandemics past we can begin to better understand our own future, and to prepare for what it holds in store.

In Pandemic: Tracking Contagions, from Cholera to Ebola and Beyond, Sonia Shah interweaves history, original reportage, and personal narrative to explore the origins of epidemics, drawing parallels between cholera—one of history’s most deadly and disruptive pandemic-causing pathogens—and the new diseases that stalk humankind today. She tracks each stage of cholera’s dramatic journey, from its emergence in the South Asian hinterlands as a harmless microbe to its rapid dispersal across the nineteenth-century world, all the way to its latest beachhead in Haiti. Along the way she reports on the pathogens now following in cholera’s footsteps, from the MRSA bacterium that besieges her own family to the never-before-seen killers coming out of China’s wet markets, the surgical wards of New Delhi, and the suburban backyards of the East Coast.

Delving into the convoluted science, strange politics, and checkered history of one of the world’s deadliest diseases, Pandemic is a work of epidemiological history like no other, with urgent lessons for our own time.